Ever wonder what’s in your dog’s meds? Do you worry about side effects? Forget to ask your veterinarian, and feel rushed when leaving? Worry about interactions with other pet meds? An obvious question arises each time our dogs are given medications! How do these work?

If your dog has been prescribed Temaril-P or if you think they should be, keep reading to find out more about this antihistamine used to relieve several conditions in dogs.

What is Temaril-P for dogs?

temaril-p for dogs

Your dog’s skin and coat health are indications as to whether your dog is experiencing adverse reactions to an allergen. Itchy and irritated skin in dogs will worsen when dogs scratch and bite the affected area of the skin surface.

This exacerbates the skin inflammation and sometimes leads to bleeding. Glucocorticoids like Temaril-P help manage chronic atopic dermatitis in dogs.

Temaril-P is composed of two active ingredients that work together: [4]

  • 5 mg of trimeprazine tartrate (USP) 10-[3-(Dimethylamino)-2-methylpropyl] phenothiazine tartrate (2:1) equivalent to trimeprazine
  • 2 mg prednisolone.

Watch Dr. Scott McKay discuss Temaril-P in more detail here:

Treatment of atopic dermatitis

Temaril-P, [1] also known as trimeprazine, is a medication that is used to manage itching in dogs and other histamine-related reactions. It also contains prednisolone, an antihistamine that helps to alleviate inflammation [2] by controlling the inflammatory pathways.

To address the inflammation issue, you’ll need to consult with your veterinarian who will most likely prescribe Temaril-P for your pooch. It is a very beneficial aid in reducing and treating itching and inflammation in dogs with chronic atopic dermatitis. [3]

Temaril-P is a corticosteroid and helps to suppress most coughs in dogs, including kennel cough, but does not help with any coughs of cardiac origin. Temaril-P helps lessen the duration of kennel cough, and of the chances of your dog infecting his friends in the vicinity. It also makes dogs feel more relaxed, and able to sleep because they are not coughing as much.

How does Temaril-P work?


When it comes to helping your pooch, Temaril-P works in three ways:

  • Antipruritic
  • Antitussive
  • Anti-inflammatory issues


Temaril-P is used to alleviate itching regardless of the cause. [5] The formula is exclusive and only used by veterinarians. It combines the antipruritic and antitussive action of trimeprazine with the anti-inflammatory effect of prednisolone (a corticosteroid).

The prednisolone helps reduce inflammation and itchiness and helps with pain from the swelling associated with inflammation by being:

  • an effective anti-itch medication, Temaril-P is prescribed by your veterinarian for the relief of itching, regardless of the cause.
  • a medication that also reduces inflammation that is usually associated with many canine skin disorders like eczema resulting from internal disorders, otitis, and dermatitis.
  • highly effective in reducing itching that is caused by allergic, inflammatory, and parasitic dermatoses.

Your veterinarian will first have to determine the cause of the pruritus and then attempt to treat it. If a correct diagnosis is not reached, the itch is likely to return when treatment is discontinued.

Temaril-P can be given to dogs that have acute or chronic bacterial infections if they are on antibiotics or chemotherapeutic medications.


Studies indicate that Temaril-P works in treating various cough conditions in dogs. Besides treating all sorts of itching, it is also used to treat kennel cough [6] or tracheobronchitis, including all allergic bronchitis, coughs, and infections.

Your veterinarian will typically first determine the cause of the cough, and then prescribe medication as a treatment. Again, if a correct diagnosis is not reached, the cough will return as soon as the medication treatment is discontinued.

Anti-inflammatory issues

Antihistamines block receptors are involved in the processes that cause itching and inflammation. Prednisolone in Temaril-P acts as an anti-inflammatory and is beneficial in reducing swelling associated with inflammation. It is a corticosteroid that also is beneficial in disease management when the immune system is affected.

Cortisol, a natural corticosteroid, is usually made by the body. It is essential for life and affects a dog’s metabolism, and all cell and organ function. Corticosteroids regulate various actions at a cellular level, and their inflammatory benefits are enormous.

Prednisolone is made when prednisone is metabolized by the liver. It is easier to absorb than Prednisone and is a better option for dogs with pre-existing liver conditions. [7]. Prednisolone also inhibits the duplication of lymphocytes.

Works together with antibiotics

When combined with antibiotics to prevent inflammation, Temaril-P can be given to dogs that have either chronic or acute bacterial infections. That said, the infection needs to be controlled with the right antibiotics or chemotherapeutic medications.

Benefits of Temaril-P for dogs

retriever lying sleeping

When our pets are felling ill, we naturally want only the best that medical science has to offer. Temaril-P has been shown to help with three primary conditions: Dermatitis, Pruritus, and bronchial issues. We’ll have a quick look at these diseases.


Most dogs will probably suffer from dermatitis at some stage in their lives. There are numerous causes of skin inflammation in dogs, including:

  • external irritants
  • burns
  • allergens
  • trauma
  • infection (bacterial, viral, parasitic, or fungal.)

Dermatitis is the result of the skin’s response to an irritant, and can manifest itself as:

  • scaling
  • itching
  • redness
  • skin thickening
  • hot spots
  • hair loss and scabbing.


Pruritus results when the skin reacts by scabbing and crusting. The inflammation will progress, and if it reaches both the upper layer of the skin (epidermis) and the deepest layer (dermis), there will be a fluid discharge combined with pain, and skin shedding.

If the dermatitis is left untreated, secondary bacterial and yeast infections develop. Temaril-P helps to suppress and reduce inflammation and prevents self-trauma from the itching until your veterinarian can diagnose the underlying cause.

Bronchial issues

Temaril-P is also used to treat allergic lung problems. It can also be used in the management of chronic bronchitis, and helps dogs feel more comfortable. By managing a persistent cough, your dog can benefit from some rest.

Temaril-P dosage for dogs


As with any veterinary treatment, it’s always necessary to follow the exact dosage that your veterinarian prescribes. Temaril-P is an oral tablet that consists of two active ingredients mixed with fillers.

Tablets are more physically and chemically stable than liquid medication. That said, tablets can have a low absorption rate of poorly water-soluble drugs, and can irritate the stomach or digestive tract lining.

Temaril-P dosages are given twice daily with food. The dosage is based on the dog’s weight accordingly:

  • half a tablet twice daily for dogs up to 10 pounds
  • one tablet twice daily for dogs weighing 11-20 pounds
  • two tablets twice daily for dogs weighing 21-40 pounds
  • three tablets daily for dogs weighing over 40 pounds.

The usual duration for this medication is four days, but if further treatment is needed, the dosage is reduced by half. Consult with your veterinarian in this regard.

Side effects of Temaril-P for dogs

While being a very effective treatment for various ailments, Temaril-P works by supressing your pets immune system, making him susceptible to secondary infections and other alarming side effects. [8]

Possible side effects of short-term use

If your dog is prescribed a short regimen of Temaril-P you can keep an eye out for the following reactions:

  • sedation
  • exposed third eyelid
  • tremors
  • weakness and lethargy
  • blood disorders
  • excessive thirst
  • excessive appetite
  • excessive urination
  • weight gain
  • panting
  • diarrhea
  • vomiting
  • behavioral changes.

Possible side effects of long-term use

The longer your dog needs to be on the medication, the more severe and prominent the side effects might be. If you observe in of the following reactions, please contact your vet who might reconsider the treatment schedule.
  • muscle Loss
  • weakness
  • development of diabetes
  • Cushing’s Disease [9]
  • thin skin
  • potbelly
  • unhealthy hair coat.

Acute reactions

If your dog shows any signs of a severe allergic reaction to Temaril-P, contact your veterinarian immediately. Symptoms include:

  • hives
  • difficulty breathing
  • swelling of face, tongue, and lips.

When should Temaril-P not be prescribed?

Pregnant, or lactating dogs should not be given this medication. Dogs that have severe fungal or bacterial infections should also not be given Temaril-P. Furthermore, dogs that have diabetes or any other chronic health conditions should not be prescribed this drug.

Temaril-P’s interaction with other drugs

dog with surgical mask

You will need to let your veterinarian know what supplements, medications, and vitamins your dog is taking prior to getting a prescription for Temaril-P since interactions may occur with the following:

  • Organophosphates
  • Procaine hydrochloride phenytoin
  • Digitalis
  • Epinephrine
  • Phenobarbital
  • Amphotericin B
  • Rifampin cyclosporine
  • Estrogens
  • Erythromycin
  • Mitotane
  • Quinidine
  • Sedatives
  • General anesthetics
  • Pain medications
  • Pepto- Bismol
  • Other antidiarrheal mixtures
  • Antacids

There is also an increased possibility of your dog getting ulcers if Temaril-P is used together with non-steroidal anti-inflammatory drugs. (NSAID’s) These include the following:

  • Aspirin
  • Carprofen (Rimadyl),
  • Deracoxib (Deramaxx)
  • Etodolac (EtoGesic)

Dogs should also not be given live vaccinations when on high doses of corticosteroids. Consult with your veterinarian about your dog’s history, vaccination schedule, and current medications.

Final thoughts on medicating with Temaril-P

maltese in grass and flowers

Sooner or later your dog will need to take medication prescribed by your veterinarian. Understanding how these veterinary medications work will help both you and your pooch! There will be some medications that can only be taken with food or some on an empty stomach.

Always consult with your veterinarian if you have any doubts regarding dosage or interactions with other medications. If your veterinarian does not discuss the side effects and possible allergic reactions to Temaril-P, inquire about them so that you’ll know what to look out for. As always, continue giving your pooch the medications until completed or otherwise instructed by your vet.


Additional medical related reads:


  1. TEMARIL-P- trimeprazine tartrate and prednisolone tablet – DailyMed
  2. Atopic itch in dogs: pharmacology and modeling.” T. Olivry. W. Bäumer. 2015.
  3. Hensel, Patrick et al. “Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification” BMC veterinary research vol. 11 196. 11 Aug. 2015, doi:10.1186/s12917-015-0515-5
  4. Temaril P Actions – GenericDrugs
  5. Cook, Christopher P et al. “Treatment of canine atopic dermatitis with cetirizine, a second generation antihistamine: a single-blinded, placebo-controlled study” Canadian veterinary journal = La revue veterinaire canadienne vol. 45,5 (2004): 414-7.
  6. The control of kennel cough.” A. Mayr. B. Mayr. 1988
  7. Side Effects of Prednisolone for Dogs – CannaPet
  9. Cushing’s disease in dogs and humans.” C. de Bruin. B. P. Meij. H. S. Kooistra. J. M.Hanson. S. W. Lamberts. L. J. Hofland. January 2009.

About the Author


Claudia Bensimoun is a hard working, animal loving, dog journalist from sunny West Palm Beach, and specializes in veterinary content. A long-time contributing features writer for Animal Wellness magazine, Fido Friendly magazine, and the United States Dog Agility Association. She's also the author and ghostwriter of more than 50 dog eBooks. She's passionate about canine nutrition, canine health and wellness, and animal rescue/adoption. Her interests include wildlife conservation, animal welfare, disaster/ humanitarian relief, and veterinary research.

Read More Posts By: Claudia


  1. Gary on May 28, 2019 at 5:21 pm

    My vet prescribed tamaril p for his allergies. I got a 2 month supply every other day Is this to long and what side effects would this have for my sweet dog. Thank you

    • Billie Walker on December 24, 2019 at 6:35 am

      My vet prescribed Temraril P for my IVDd dog for allergies. One pill for 7 Days. Will it hurt him? He does have IVDD and had three surgeries. 2 on back and one on his neck several years ago. He is eating and running and feels okay. He spit up yellow junk one time yesterday.

  2. Roberta Spiegel on May 2, 2020 at 5:24 pm

    My Pom has a collapsed trachea and has been taking hydrocodone, He was just give Temaril P. He is now getting only I]/2 pill every other day. Is it OK to give him the hydrocodone also?

  3. Karen on September 3, 2021 at 4:25 am

    I have a 9 year old Chihuahua terrier With heart disease 1st stages of kidney failure His heart medications My vet just prescribed this medication For an onset continuing cough. When I give my boy This medication he starts breathing hard And rapid Breathing pantingIs he having an allergic reactionOr something I’m just very very concerned. He’s not doing that when I give him his other medications.

  4. mona Shipley on January 8, 2022 at 2:47 pm

    The vet prescribed temarip p for itching and it doesn’t help with it should I stop Temarip p and go to benadryl? He is a 17 yr old Bichon who we rescued 5yrs ago .this itching is out of control his miserable and we are considering putting dog down to stop his anguish! Did scraping clear did injection no help tried temaril p not helping! Should I stop Temaril p and go to benadryl?

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